Hepatitis Monthly Hepatitis Monthly Hepat Mon http://www.hepatmon.portal.tools 1735-143X 1735-3408 10.5812/hepatmon en jalali 2019 9 16 gregorian 2019 9 16 14 5
en 24910706 10.5812/hepatmon.18794 Long Noncoding RNAs in Interaction With RNA Binding Proteins in Hepatocellular Carcinoma Long Noncoding RNAs in Interaction With RNA Binding Proteins in Hepatocellular Carcinoma research-article research-article Conclusions

This information provides an explanation for the previously valuable literature on the functions of lncRNAs and suggest for the novel therapeutic targeting.

Results

The lncRNAs HOTTIP, H19, HOTAIR, MALAT1, antisense Igf2r (AIR), HOXA13, GTL2 (also called MEG3) and uc002mb have been reported in association with HCC. Besides, this study predicted that eIF4AIII, PTB and FUS were the most involved RBPs in interaction with HCC-related lncRNAs.

Materials and Methods

The identified lncRNAs were analyzed by bioinformatics tools, starBase and lncRNA db, to anticipate the RNA-binding proteins (RBPs) that tend to interact to HCC-related lncRNAs. The most important predicted RBPs in interaction with well-known lncRNAs in HCC were briefly discussed.

Background

Gene expression microarrays' analyses provide a description of long noncoding RNAs (lncRNAs) with lack of coding protein function that is often important in human cancer.

Objectives

A number of lncRNAs that have been well characterized in hepatocellular carcinoma (HCC) have been scheduled in this study to discuss for protein–lncRNA interaction.

Conclusions

This information provides an explanation for the previously valuable literature on the functions of lncRNAs and suggest for the novel therapeutic targeting.

Results

The lncRNAs HOTTIP, H19, HOTAIR, MALAT1, antisense Igf2r (AIR), HOXA13, GTL2 (also called MEG3) and uc002mb have been reported in association with HCC. Besides, this study predicted that eIF4AIII, PTB and FUS were the most involved RBPs in interaction with HCC-related lncRNAs.

Materials and Methods

The identified lncRNAs were analyzed by bioinformatics tools, starBase and lncRNA db, to anticipate the RNA-binding proteins (RBPs) that tend to interact to HCC-related lncRNAs. The most important predicted RBPs in interaction with well-known lncRNAs in HCC were briefly discussed.

Background

Gene expression microarrays' analyses provide a description of long noncoding RNAs (lncRNAs) with lack of coding protein function that is often important in human cancer.

Objectives

A number of lncRNAs that have been well characterized in hepatocellular carcinoma (HCC) have been scheduled in this study to discuss for protein–lncRNA interaction.

Carcinoma, Hepatocellular;Long Noncoding RNA;RNA-Binding Proteins Carcinoma, Hepatocellular;Long Noncoding RNA;RNA-Binding Proteins http://www.hepatmon.portal.tools/index.php?page=article&article_id=18794 Ashraf Mohamadkhani Ashraf Mohamadkhani Liver and Pancreatobiliary Disease Research Center, Digestive Disease Research institute, Shartati Hospital, Tehran University of Medical Sciences, Tehran, IR Iran; Liver and Pancreatobiliary Disease Research Center, Digestive Disease Research institute, Shartati Hospital, Tehran University of Medical Sciences, North Kargar Ave. Tehran, IR Iran. Tel: +98-2182415227, Fax: +98-2182415400 Liver and Pancreatobiliary Disease Research Center, Digestive Disease Research institute, Shartati Hospital, Tehran University of Medical Sciences, Tehran, IR Iran; Liver and Pancreatobiliary Disease Research Center, Digestive Disease Research institute, Shartati Hospital, Tehran University of Medical Sciences, North Kargar Ave. Tehran, IR Iran. Tel: +98-2182415227, Fax: +98-2182415400